Assay Detail
Functional
CHEMBL1038902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiangiogenic activity in chicken embryo chorioallantoic membrane assessed as inhibition of VEGF/bFGF-induced blood vessel formation treated 8 hrs after VEGF/bFGF challenge measured after 40 hrs
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Gallus gallus |
| Tissue | Chorioallantoic membrane |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.32 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 7.52 |
| CHEMBL610181 | — | — | 1 | 7.10 |
| CHEMBL604879 | — | — | 1 | 5.70 |
| CHEMBL594320 | — | — | 1 | 5.30 |
| CHEMBL595757 | — | — | 1 | 5.30 |
| CHEMBL603198 | — | — | 1 | 5.28 |
| CHEMBL594339 | — | — | 1 | 5.25 |
| CHEMBL594810 | — | — | 1 | 5.23 |
| CHEMBL606362 | — | — | 1 | 5.03 |
| CHEMBL594790 | — | — | 1 | 4.97 |
| CHEMBL605413 | — | — | 1 | 4.93 |
| CHEMBL593154 | — | — | 1 | 4.78 |
| CHEMBL606039 | — | — | 1 | 4.75 |
| CHEMBL595497 | — | — | 1 | 4.65 |
| CHEMBL603849 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276711 | SEMAXANIB | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL610181 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL604879 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL594320 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL595757 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL603198 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL594339 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL594810 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL606362 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL594790 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL605413 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL593154 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL606039 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL595497 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL603849 | — | IC50 | = | 92200.0 | nM | 4.04 |