Assay Detail
Binding
CHEMBL1039055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiprion activity against Scrapie prion protein-mediated scrapie in mouse ScNB cells assessed as PrP-res accumulation after 4 days by immunoblotting
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationship of indole-3-glyoxylamide libraries possessing highly potent activity in a cell line model of prion disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 8.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | EC50 | = | 10.0 | nM | 8.00 |