Assay Detail
Binding
CHEMBL1039597
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]mesulergine from 5HT2C in Sprague-Dawley rat brain cortex by liquid scintillation counting
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.21 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566533 | — | — | 1 | 8.89 |
| CHEMBL12314 | MESULERGINE | 2.0 | 1 | 8.72 |
| CHEMBL586050 | — | — | 1 | 7.40 |
| CHEMBL583422 | — | — | 1 | 7.36 |
| CHEMBL568284 | — | — | 1 | 7.35 |
| CHEMBL565707 | — | — | 1 | 7.30 |
| CHEMBL567649 | — | — | 1 | 6.98 |
| CHEMBL565484 | — | — | 1 | 6.61 |
| CHEMBL584919 | — | — | 1 | 6.51 |
| CHEMBL568285 | — | — | 1 | 5.00 |
| CHEMBL566331 | — | — | 1 | - |
| CHEMBL567834 | — | — | 1 | - |
| CHEMBL567648 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566533 | — | Ki | = | 1.28 | nM | 8.89 |
| CHEMBL12314 | MESULERGINE | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL586050 | — | Ki | = | 39.7 | nM | 7.40 |
| CHEMBL583422 | — | Ki | = | 43.6 | nM | 7.36 |
| CHEMBL568284 | — | Ki | = | 45.1 | nM | 7.35 |
| CHEMBL565707 | — | Ki | = | 50.4 | nM | 7.30 |
| CHEMBL567649 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL565484 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL584919 | — | Ki | = | 309.0 | nM | 6.51 |
| CHEMBL568285 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL566331 | — | Ki | - | — | - | |
| CHEMBL567834 | — | Ki | - | — | - | |
| CHEMBL567648 | — | Ki | - | — | - |