Assay Detail
Functional
CHEMBL1039902
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Antiviral activity against HIV RF infected in human SupT1 cells
26
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Cell Type | SUP-T1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.47 | 9.22 |
| IC90 | 13 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 2 | 9.22 |
| CHEMBL577718 | — | — | 2 | 9.17 |
| CHEMBL576256 | — | — | 2 | 9.05 |
| CHEMBL567510 | — | — | 2 | 9.03 |
| CHEMBL435128 | CAPRAVIRINE | 2.0 | 2 | 8.85 |
| CHEMBL568575 | — | — | 2 | 8.52 |
| CHEMBL567916 | — | — | 2 | 8.52 |
| CHEMBL571987 | LERSIVIRINE | 2.0 | 2 | 8.40 |
| CHEMBL577271 | — | — | 2 | 8.24 |
| CHEMBL565830 | — | — | 2 | 8.08 |
| CHEMBL565829 | — | — | 2 | 7.77 |
| CHEMBL567509 | — | — | 2 | 7.66 |
| CHEMBL566470 | — | — | 2 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL577718 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL576256 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL567510 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL435128 | CAPRAVIRINE | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL568575 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL567916 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL571987 | LERSIVIRINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL577271 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL565830 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL565829 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL567509 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL566470 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL435128 | CAPRAVIRINE | IC90 | = | 2.4 | nM | - |
| CHEMBL223228 | EFAVIRENZ | IC90 | = | 1.2 | nM | - |
| CHEMBL577271 | — | IC90 | = | 25.0 | nM | - |
| CHEMBL571987 | LERSIVIRINE | IC90 | = | 25.0 | nM | - |
| CHEMBL567510 | — | IC90 | = | 5.4 | nM | - |
| CHEMBL568575 | — | IC90 | = | 3.0 | nM | - |
| CHEMBL565829 | — | IC90 | = | 59.0 | nM | - |
| CHEMBL567916 | — | IC90 | = | 18.0 | nM | - |
| CHEMBL576256 | — | IC90 | = | 6.7 | nM | - |
| CHEMBL566470 | — | IC90 | = | 131.0 | nM | - |
| CHEMBL567509 | — | IC90 | = | 100.0 | nM | - |
| CHEMBL565830 | — | IC90 | = | 2.4 | nM | - |
| CHEMBL577718 | — | IC90 | = | 3.5 | nM | - |