Assay Detail
ADMET
CHEMBL1040022
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Cytotoxicity against human 8392B cells after 48 hrs by trypan blue exclusion assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity studies of urea, carbamate, and sulfonamide derivatives of acylfulvene.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.20 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | 3.0 | 1 | 7.12 |
| CHEMBL584542 | — | — | 1 | 6.60 |
| CHEMBL583686 | — | — | 1 | 6.21 |
| CHEMBL585543 | — | — | 1 | 5.54 |
| CHEMBL578213 | — | — | 1 | 5.48 |
| CHEMBL571645 | — | — | 1 | 5.33 |
| CHEMBL571624 | — | — | 1 | 5.30 |
| CHEMBL571662 | — | — | 1 | 5.18 |
| CHEMBL571653 | — | — | 1 | 5.15 |
| CHEMBL571609 | — | — | 1 | 5.05 |
| CHEMBL571024 | — | — | 1 | 5.01 |
| CHEMBL585158 | — | — | 1 | 4.58 |
| CHEMBL572110 | — | — | 1 | 4.55 |
| CHEMBL584747 | — | — | 1 | 4.42 |
| CHEMBL583140 | — | — | 1 | 4.38 |
| CHEMBL572267 | — | — | 1 | 4.27 |
| CHEMBL571427 | — | — | 1 | 4.21 |
| CHEMBL572066 | — | — | 1 | - |
| CHEMBL578828 | — | — | 1 | - |
| CHEMBL576044 | — | — | 1 | - |
| CHEMBL578829 | — | — | 1 | - |
| CHEMBL572067 | — | — | 1 | - |
| CHEMBL571644 | — | — | 1 | - |
| CHEMBL571025 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL584542 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL583686 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL585543 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL578213 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL571645 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL571624 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL571662 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL571653 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL571609 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL571024 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL585158 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL572110 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL584747 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL583140 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL572267 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL571427 | — | IC50 | = | 62200.0 | nM | 4.21 |
| CHEMBL572066 | — | IC50 | > | 2800.0 | nM | - |
| CHEMBL578828 | — | IC50 | > | 8500.0 | nM | - |
| CHEMBL576044 | — | IC50 | > | 9000.0 | nM | - |
| CHEMBL578829 | — | IC50 | > | 9000.0 | nM | - |
| CHEMBL572067 | — | IC50 | > | 9300.0 | nM | - |
| CHEMBL571644 | — | IC50 | > | 9300.0 | nM | - |
| CHEMBL571025 | — | IC50 | > | 9400.0 | nM | - |