Assay Detail
Binding
CHEMBL1040202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to 5-HT2B receptor
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.80 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569251 | — | — | 2 | 8.22 |
| CHEMBL566396 | — | — | 1 | 6.96 |
| CHEMBL566356 | — | — | 1 | 6.78 |
| CHEMBL566379 | — | — | 2 | 6.40 |
| CHEMBL569513 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569251 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL566396 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL569251 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL566356 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL566379 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL566379 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL569513 | — | Ki | = | 680.0 | nM | 6.17 |