Assay Detail
Binding
CHEMBL1040205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to alpha1 adrenergic receptor in rat brain membrane by radioligand binding assay
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.73 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569251 | — | — | 2 | 9.30 |
| CHEMBL566379 | — | — | 2 | 7.66 |
| CHEMBL566356 | — | — | 1 | 7.19 |
| CHEMBL566396 | — | — | 1 | 6.89 |
| CHEMBL569513 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569251 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL569251 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL566379 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL566379 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL566356 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL566396 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL569513 | — | Ki | = | 220.0 | nM | 6.66 |