Assay Detail
Binding
CHEMBL1040323
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Inhibition of human GBA2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574645 | — | — | 1 | 9.00 |
| CHEMBL1029 | MIGLUSTAT | 4.0 | 1 | 6.64 |
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | 4.70 |
| CHEMBL574865 | — | — | 1 | - |
| CHEMBL583176 | — | — | 1 | - |
| CHEMBL573995 | — | — | 1 | - |
| CHEMBL584580 | — | — | 1 | - |
| CHEMBL577370 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574645 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1029 | MIGLUSTAT | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL574865 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL583176 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL573995 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL584580 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL577370 | — | IC50 | > | 1000000.0 | nM | - |