Assay Detail
Binding
CHEMBL1040331
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Inhibition of GST-tagged VEGFR expressed in Sf9 cells
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.13 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489326 | EXELIXIS | — | 1 | 8.15 |
| CHEMBL462232 | — | — | 1 | 8.10 |
| CHEMBL573761 | — | — | 1 | 8.00 |
| CHEMBL574225 | — | — | 1 | 7.82 |
| CHEMBL577369 | — | — | 1 | 7.70 |
| CHEMBL574864 | — | — | 1 | 7.70 |
| CHEMBL575713 | — | — | 1 | 7.70 |
| CHEMBL582927 | — | — | 1 | 7.70 |
| CHEMBL572389 | — | — | 1 | 7.70 |
| CHEMBL254760 | — | — | 1 | 7.58 |
| CHEMBL574870 | — | — | 1 | 7.52 |
| CHEMBL574125 | — | — | 1 | 7.52 |
| CHEMBL576752 | — | — | 1 | 7.52 |
| CHEMBL573974 | — | — | 1 | 7.52 |
| CHEMBL575698 | — | — | 1 | 7.52 |
| CHEMBL404881 | — | — | 1 | 7.50 |
| CHEMBL574093 | — | — | 1 | 7.40 |
| CHEMBL576769 | — | — | 1 | 7.30 |
| CHEMBL575076 | — | — | 1 | 7.00 |
| CHEMBL574050 | — | — | 1 | 6.92 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 6.73 |
| CHEMBL582925 | — | — | 1 | 6.68 |
| CHEMBL573768 | — | — | 1 | 6.64 |
| CHEMBL575712 | — | — | 1 | 6.43 |
| CHEMBL574406 | — | — | 1 | 6.22 |
| CHEMBL574628 | — | — | 1 | 6.20 |
| CHEMBL450786 | PHA-665752 | — | 1 | 6.06 |
| CHEMBL574230 | — | — | 1 | 5.89 |
| CHEMBL573762 | — | — | 1 | 5.85 |
| CHEMBL575490 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489326 | EXELIXIS | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL462232 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL573761 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL574225 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL577369 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL574864 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL575713 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL582927 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL572389 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL254760 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL574870 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL574125 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL576752 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL573974 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL575698 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL404881 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL574093 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL576769 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL575076 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL574050 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL535 | SUNITINIB | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL582925 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL573768 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL575712 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL574406 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL574628 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 863.0 | nM | 6.06 |
| CHEMBL574230 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL573762 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL575490 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL573765 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL574863 | — | IC50 | > | 2000.0 | nM | - |