Compound Detail
CHEMBL582925
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Basic Information
| ChEMBL ID | CHEMBL582925 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JHUZYTFKCRADAF-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
508.6
MW (Da)
5.79
ALogP
6
HBA
1
HBD
93.2
PSA (Ų)
0.45
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 6.96 | 6.515 | 110.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 6.68 | 6.68 | 210.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 110.0 | nM | 6.96 | Inhibition of GST-tagged c-Met expressed in Sf9 cells | 19854051 |
| Unchecked | IC50 | = | 210.0 | nM | 6.68 | Inhibition of GST-tagged VEGFR expressed in Sf9 cells | 19854051 |
| Hepatocyte growth factor receptor | IC50 | = | 860.0 | nM | 6.07 | Inhibition of TPR-Met assessed as autophosphorylation | 19854051 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19854051 | 10.1016/j.bmcl.2009.10.040 | Hepatocyte growth factor receptor | 2 |
| 19854051 | 10.1016/j.bmcl.2009.10.040 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine