Assay Detail
Binding
CHEMBL1040332
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Inhibition of TPR-Met assessed as autophosphorylation
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.69 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574093 | — | — | 1 | 7.70 |
| CHEMBL574050 | — | — | 1 | 7.52 |
| CHEMBL574125 | — | — | 1 | 7.30 |
| CHEMBL582927 | — | — | 1 | 7.10 |
| CHEMBL575076 | — | — | 1 | 7.10 |
| CHEMBL573761 | — | — | 1 | 7.05 |
| CHEMBL574864 | — | — | 1 | 7.05 |
| CHEMBL572389 | — | — | 1 | 6.89 |
| CHEMBL575698 | — | — | 1 | 6.82 |
| CHEMBL576752 | — | — | 1 | 6.82 |
| CHEMBL574225 | — | — | 1 | 6.70 |
| CHEMBL573974 | — | — | 1 | 6.62 |
| CHEMBL577369 | — | — | 1 | 6.43 |
| CHEMBL574406 | — | — | 1 | 6.20 |
| CHEMBL575712 | — | — | 1 | 6.19 |
| CHEMBL582925 | — | — | 1 | 6.07 |
| CHEMBL573765 | — | — | 1 | 5.48 |
| CHEMBL574230 | — | — | 1 | 5.30 |
| CHEMBL574628 | — | — | 1 | - |
| CHEMBL573768 | — | — | 1 | - |
| CHEMBL575490 | — | — | 1 | - |
| CHEMBL573762 | — | — | 1 | - |
| CHEMBL574863 | — | — | 1 | - |
| CHEMBL574870 | — | — | 1 | - |
| CHEMBL576769 | — | — | 1 | - |
| CHEMBL575713 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574093 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL574050 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL574125 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL582927 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL575076 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL573761 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL574864 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL572389 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL575698 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL576752 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL574225 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL573974 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL577369 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL574406 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL575712 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL582925 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL573765 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL574230 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL574628 | — | IC50 | - | — | - | |
| CHEMBL573768 | — | IC50 | - | — | - | |
| CHEMBL575490 | — | IC50 | - | — | - | |
| CHEMBL573762 | — | IC50 | - | — | - | |
| CHEMBL574863 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL574870 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL576769 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL575713 | — | IC50 | > | 10000.0 | nM | - |