Assay Detail
Binding
CHEMBL1040334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full length mitochondrial carbonic anhydrase 5B after 15 mins by stopped-flow CO2 hydration assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Carbonic anhydrase 5B, mitochondrial (CHEMBL3969) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.44 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.48 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.27 |
| CHEMBL24261 | OCTYL SULFAMATE | — | 1 | 6.21 |
| CHEMBL153094 | DECYL SULFAMATE | — | 1 | 6.05 |
| CHEMBL182455 | — | — | 1 | 5.84 |
| CHEMBL171476 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL24261 | OCTYL SULFAMATE | Ki | = | 624.0 | nM | 6.21 |
| CHEMBL153094 | DECYL SULFAMATE | Ki | = | 888.0 | nM | 6.05 |
| CHEMBL182455 | — | Ki | = | 1457.0 | nM | 5.84 |
| CHEMBL171476 | — | Ki | = | 1592.0 | nM | 5.80 |