Assay Detail
Binding
CHEMBL1040548
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Inhibition of CDK1/cyclin B expressed in M phase starfish oocyte
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.84 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299756 | PAULLONE 2 | — | 1 | 7.62 |
| CHEMBL50894 | ALSTERPAULLONE | — | 1 | 7.46 |
| CHEMBL325654 | — | — | 1 | 7.36 |
| CHEMBL319373 | — | — | 1 | 6.70 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 6.40 |
| CHEMBL329505 | — | — | 1 | 6.40 |
| CHEMBL98153 | — | — | 1 | 6.22 |
| CHEMBL318471 | — | — | 1 | 5.85 |
| CHEMBL99037 | — | — | 1 | 5.80 |
| CHEMBL317964 | — | — | 1 | 5.70 |
| CHEMBL316512 | — | — | 1 | 5.60 |
| CHEMBL318208 | — | — | 1 | 5.21 |
| CHEMBL430574 | PAULLONE | — | 1 | 5.16 |
| CHEMBL316485 | — | — | 1 | 4.70 |
| CHEMBL99779 | PAULLONE | — | 1 | 4.46 |
| CHEMBL95477 | — | — | 1 | 4.40 |
| CHEMBL99280 | — | — | 1 | 4.22 |
| CHEMBL330398 | — | — | 1 | - |
| CHEMBL99423 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299756 | PAULLONE 2 | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL325654 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL319373 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL329505 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL98153 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL318471 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL99037 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL317964 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL316512 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL318208 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL430574 | PAULLONE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL316485 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL99779 | PAULLONE | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL95477 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL99280 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL330398 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL99423 | — | IC50 | = | 430000.0 | nM | - |