Assay Detail
Binding
CHEMBL1040775
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Inhibition of bovine COX-1 by enzyme immuno assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.60 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 6.46 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.54 |
| CHEMBL578389 | — | — | 1 | 4.81 |
| CHEMBL571658 | — | — | 1 | - |
| CHEMBL571852 | — | — | 1 | - |
| CHEMBL579022 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL578389 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL571658 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL571852 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL579022 | — | IC50 | > | 100000.0 | nM | - |