Assay Detail
Functional
CHEMBL1041084
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Antiviral activity against HIV1 NL4-3 infected in human TZM-bl cells assessed as inhibition of viral replication
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.55 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 9.21 |
| CHEMBL569259 | — | — | 1 | 9.17 |
| CHEMBL566806 | — | — | 1 | 8.78 |
| CHEMBL566153 | — | — | 1 | 8.40 |
| CHEMBL569051 | — | — | 1 | 8.17 |
| CHEMBL569258 | — | — | 1 | 8.12 |
| CHEMBL577081 | — | — | 1 | 7.96 |
| CHEMBL569520 | — | — | 1 | 7.66 |
| CHEMBL567462 | — | — | 1 | 7.64 |
| CHEMBL569494 | — | — | 1 | 7.21 |
| CHEMBL566152 | — | — | 1 | 6.96 |
| CHEMBL565323 | — | — | 1 | 6.63 |
| CHEMBL566594 | — | — | 1 | 6.62 |
| CHEMBL585572 | — | — | 1 | 6.32 |
| CHEMBL568535 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | EC50 | = | 0.62 | nM | 9.21 |
| CHEMBL569259 | — | EC50 | = | 0.68 | nM | 9.17 |
| CHEMBL566806 | — | EC50 | = | 1.67 | nM | 8.78 |
| CHEMBL566153 | — | EC50 | = | 4.02 | nM | 8.40 |
| CHEMBL569051 | — | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL569258 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL577081 | — | EC50 | = | 10.9 | nM | 7.96 |
| CHEMBL569520 | — | EC50 | = | 22.1 | nM | 7.66 |
| CHEMBL567462 | — | EC50 | = | 22.9 | nM | 7.64 |
| CHEMBL569494 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL566152 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL565323 | — | EC50 | = | 234.0 | nM | 6.63 |
| CHEMBL566594 | — | EC50 | = | 241.0 | nM | 6.62 |
| CHEMBL585572 | — | EC50 | = | 477.0 | nM | 6.32 |
| CHEMBL568535 | — | EC50 | = | 41346.0 | nM | 4.38 |