Assay Detail
Functional
CHEMBL1041085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 RTMDR1 infected in human TZM-bl cells assessed as inhibition of viral replication
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.49 | 9.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 9.53 |
| CHEMBL569259 | — | — | 1 | 9.02 |
| CHEMBL566806 | — | — | 1 | 8.92 |
| CHEMBL566153 | — | — | 1 | 8.42 |
| CHEMBL569258 | — | — | 1 | 8.29 |
| CHEMBL569051 | — | — | 1 | 8.04 |
| CHEMBL569520 | — | — | 1 | 7.68 |
| CHEMBL577081 | — | — | 1 | 7.60 |
| CHEMBL567462 | — | — | 1 | 7.26 |
| CHEMBL569494 | — | — | 1 | 7.03 |
| CHEMBL565323 | — | — | 1 | 6.89 |
| CHEMBL566152 | — | — | 1 | 6.67 |
| CHEMBL566594 | — | — | 1 | 6.28 |
| CHEMBL585572 | — | — | 1 | 6.06 |
| CHEMBL568535 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | EC50 | = | 0.298 | nM | 9.53 |
| CHEMBL569259 | — | EC50 | = | 0.96 | nM | 9.02 |
| CHEMBL566806 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL566153 | — | EC50 | = | 3.78 | nM | 8.42 |
| CHEMBL569258 | — | EC50 | = | 5.13 | nM | 8.29 |
| CHEMBL569051 | — | EC50 | = | 9.03 | nM | 8.04 |
| CHEMBL569520 | — | EC50 | = | 21.1 | nM | 7.68 |
| CHEMBL577081 | — | EC50 | = | 25.1 | nM | 7.60 |
| CHEMBL567462 | — | EC50 | = | 55.2 | nM | 7.26 |
| CHEMBL569494 | — | EC50 | = | 94.3 | nM | 7.03 |
| CHEMBL565323 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL566152 | — | EC50 | = | 215.0 | nM | 6.67 |
| CHEMBL566594 | — | EC50 | = | 531.0 | nM | 6.28 |
| CHEMBL585572 | — | EC50 | = | 877.0 | nM | 6.06 |
| CHEMBL568535 | — | EC50 | = | 25480.0 | nM | 4.59 |