Assay Detail
Binding
CHEMBL1041182
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Inhibition of mouse full length cytosolic carbonic anhydrase 13 after 15 mins by stopped-flow CO2 hydration assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.63 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.77 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.75 |
| CHEMBL182455 | — | — | 1 | 6.25 |
| CHEMBL153094 | DECYL SULFAMATE | — | 1 | 6.02 |
| CHEMBL171476 | — | — | 1 | 6.02 |
| CHEMBL24261 | OCTYL SULFAMATE | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL182455 | — | Ki | = | 569.0 | nM | 6.25 |
| CHEMBL153094 | DECYL SULFAMATE | Ki | = | 956.0 | nM | 6.02 |
| CHEMBL171476 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL24261 | OCTYL SULFAMATE | Ki | = | 1125.0 | nM | 5.95 |