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Evidence Snapshot

Carbonic anhydrase 13

CHEMBL2186 SINGLE PROTEIN Mus musculus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T23:51:41Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2186
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Carbonic anhydrase 13 as ChEMBL target CHEMBL2186, mapped to UniProt Q9D6N1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Carbonic anhydrase 13
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL2186
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9D6N1
Carbonic anhydrase 13
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Carbonic anhydrase 13 matters

As of 2026-09-13

Carbonic anhydrase 13 is reviewed as Carbonic anhydrase 13 (UniProt Q9D6N1); the current evidence base includes 22 approved drugs, 200 compounds, and 45 assays, with lead potency reaching pChEMBL 8.9.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 22 approved drugs, 200 compounds, and 45 assays for this target. The dominant activity type is KI. CHEMBL7146 is the current potency anchor at pChEMBL 8.9.

Use CHEMBL7146 as the tractability anchor when discussing potency (pChEMBL 8.9).

Activity source · ChEMBL 36 via Core Engine
22 approved pChEMBL 8.9
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Carbonic anhydrase 13 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q9D6N1, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

200
Total Compounds
45
Total Assays
22
Approved Drugs
IC50: 5.0, KI: 215.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL7146
 8.9 Ki —
No preferred name
CHEMBL266026
 8.7 Ki —
No preferred name
CHEMBL268439
 8.7 Ki —
No preferred name
CHEMBL269122
 8.6 Ki —
No preferred name
CHEMBL220491
 8.0 Ki Approved

Approved Drugs

Structure Compound First Approval
VALDECOXIB
CHEMBL865
 2001
BRINZOLAMIDE
CHEMBL220491
 1998
TOPIRAMATE
CHEMBL220492
 1996
DORZOLAMIDE
CHEMBL218490
 1994
SULFANILAMIDE
CHEMBL21
 1985
INDAPAMIDE
CHEMBL406
 1983
ETHOXZOLAMIDE
CHEMBL18
 1982
MAFENIDE
CHEMBL419
 1969
FUROSEMIDE
CHEMBL35
 1966
CHLORTHALIDONE
CHEMBL1055
 1960
TRICHLORMETHIAZIDE
CHEMBL1054
 1960
METHAZOLAMIDE
CHEMBL19
 1959
DICHLORPHENAMIDE
CHEMBL17
 1958
ACETAZOLAMIDE
CHEMBL20
 1953
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T23:51:41Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2186