Assay Detail
Binding
CHEMBL1041236
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Inhibition of human recombinant AChE in erythrocytes by Ellman's assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.04 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208599 | HUPRINE X | — | 1 | 8.96 |
| CHEMBL140476 | HUPRINE Y | — | 1 | 8.73 |
| CHEMBL575802 | — | — | 1 | 8.40 |
| CHEMBL575674 | — | — | 1 | 8.22 |
| CHEMBL573095 | — | — | 1 | 8.17 |
| CHEMBL574973 | — | — | 1 | 8.06 |
| CHEMBL583920 | — | — | 1 | 8.02 |
| CHEMBL574974 | — | — | 1 | 7.86 |
| CHEMBL576385 | — | — | 1 | 7.36 |
| CHEMBL575614 | — | — | 1 | 6.18 |
| CHEMBL575613 | — | — | 1 | 6.09 |
| CHEMBL584603 | — | — | 1 | 6.07 |
| CHEMBL576004 | — | — | 1 | 5.60 |
| CHEMBL575167 | — | — | 1 | 5.54 |
| CHEMBL574746 | — | — | 1 | 5.32 |
| CHEMBL573094 | — | — | 1 | 5.29 |
| CHEMBL583776 | — | — | 1 | 5.19 |
| CHEMBL576384 | — | — | 1 | 5.14 |
| CHEMBL574261 | — | — | 1 | 5.11 |
| CHEMBL575810 | — | — | 1 | 5.09 |
| CHEMBL574267 | — | — | 1 | 4.93 |
| CHEMBL575166 | — | — | 1 | 4.83 |
| CHEMBL572866 | — | — | 1 | 4.72 |
| CHEMBL572865 | — | — | 1 | 4.65 |
| CHEMBL576189 | — | — | 1 | 4.57 |
| CHEMBL574948 | — | — | 1 | 4.30 |
| CHEMBL572858 | — | — | 1 | 4.30 |
| CHEMBL584003 | — | — | 1 | 4.30 |
| CHEMBL574747 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208599 | HUPRINE X | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL140476 | HUPRINE Y | IC50 | = | 1.84 | nM | 8.73 |
| CHEMBL575802 | — | IC50 | = | 3.95 | nM | 8.40 |
| CHEMBL575674 | — | IC50 | = | 5.96 | nM | 8.22 |
| CHEMBL573095 | — | IC50 | = | 6.75 | nM | 8.17 |
| CHEMBL574973 | — | IC50 | = | 8.69 | nM | 8.06 |
| CHEMBL583920 | — | IC50 | = | 9.66 | nM | 8.02 |
| CHEMBL574974 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL576385 | — | IC50 | = | 43.3 | nM | 7.36 |
| CHEMBL575614 | — | IC50 | = | 664.0 | nM | 6.18 |
| CHEMBL575613 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL584603 | — | IC50 | = | 855.0 | nM | 6.07 |
| CHEMBL576004 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL575167 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL574746 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL573094 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL583776 | — | IC50 | = | 6450.0 | nM | 5.19 |
| CHEMBL576384 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL574261 | — | IC50 | = | 7690.0 | nM | 5.11 |
| CHEMBL575810 | — | IC50 | = | 8080.0 | nM | 5.09 |
| CHEMBL574267 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL575166 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL572866 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL572865 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL576189 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL574948 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL572858 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL584003 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL574747 | — | IC50 | = | 50000.0 | nM | 4.30 |