Assay Detail
Binding
CHEMBL1041237
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Inhibition of human recombinant BuChE by Ellman's assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.91 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575613 | — | — | 1 | 6.47 |
| CHEMBL574974 | — | — | 1 | 6.08 |
| CHEMBL574973 | — | — | 1 | 5.63 |
| CHEMBL573095 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575613 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL574974 | — | IC50 | = | 824.0 | nM | 6.08 |
| CHEMBL574973 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL573095 | — | IC50 | = | 3640.0 | nM | 5.44 |