Assay Detail
Binding
CHEMBL1041329
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.63 | 8.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574558 | — | — | 1 | 8.71 |
| CHEMBL582945 | — | — | 1 | 6.84 |
| CHEMBL585741 | — | — | 1 | 6.66 |
| CHEMBL286080 | SKF-38393 | — | 1 | 6.41 |
| CHEMBL585742 | — | — | 1 | 6.31 |
| CHEMBL574595 | — | — | 1 | 6.30 |
| CHEMBL574700 | — | — | 1 | 6.26 |
| CHEMBL585740 | — | — | 1 | 6.18 |
| CHEMBL574627 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574558 | — | Ki | = | 1.93 | nM | 8.71 |
| CHEMBL582945 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL585741 | — | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL286080 | SKF-38393 | Ki | = | 393.0 | nM | 6.41 |
| CHEMBL585742 | — | Ki | = | 492.0 | nM | 6.31 |
| CHEMBL574595 | — | Ki | = | 501.0 | nM | 6.30 |
| CHEMBL574700 | — | Ki | = | 551.0 | nM | 6.26 |
| CHEMBL585740 | — | Ki | = | 655.0 | nM | 6.18 |
| CHEMBL574627 | — | Ki | = | 963.0 | nM | 6.02 |