Assay Detail
Functional
CHEMBL1041661
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Antiviral activity against 100 TCID50 HIV1 infected in human TZM-b1 cells assessed as inhibition of viral replication by pseudovirus based assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-b1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Highly suppressing wild-type HIV-1 and Y181C mutant HIV-1 strains by 10-chloromethyl-11-demethyl-12-oxo-calanolide A with druggable profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.51 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL583253 | — | — | 1 | 8.13 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 8.09 |
| CHEMBL566605 | CIS-10,11-CYCLOPROPYL-12-OXO-CALANOLIDE A | — | 1 | 7.85 |
| CHEMBL267447 | CALANOLIDE A | 1.0 | 1 | 7.00 |
| CHEMBL411936 | — | — | 1 | 6.75 |
| CHEMBL569161 | — | — | 1 | 6.75 |
| CHEMBL566821 | — | — | 1 | 6.34 |
| CHEMBL569471 | — | — | 1 | 4.84 |
| CHEMBL583909 | — | — | 1 | 4.83 |
| CHEMBL569472 | — | — | 1 | 4.47 |
| CHEMBL569856 | — | — | 1 | - |
| CHEMBL571842 | — | — | 1 | - |
| CHEMBL571239 | — | — | 1 | - |
| CHEMBL566601 | — | — | 1 | - |
| CHEMBL565539 | — | — | 1 | - |
| CHEMBL584103 | — | — | 1 | - |
| CHEMBL567227 | — | — | 1 | - |
| CHEMBL577730 | — | — | 1 | - |
| CHEMBL572214 | 1'-AMINEMETHYL-11-DEMETHYL-12-OXO-CALANOLIDE A | — | 1 | - |
| CHEMBL572213 | 1'-AZIDEMETHYL-11-DEMETHYL-12-OXO-CALANOLIDE A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL583253 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL566605 | CIS-10,11-CYCLOPROPYL-12-OXO-CALANOLIDE A | EC50 | = | 14.1 | nM | 7.85 |
| CHEMBL267447 | CALANOLIDE A | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL411936 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL569161 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL566821 | — | EC50 | = | 456.0 | nM | 6.34 |
| CHEMBL569471 | — | EC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL583909 | — | EC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL569472 | — | EC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL569856 | — | EC50 | - | — | - | |
| CHEMBL571842 | — | EC50 | - | — | - | |
| CHEMBL571239 | — | EC50 | - | — | - | |
| CHEMBL566601 | — | EC50 | - | — | - | |
| CHEMBL565539 | — | EC50 | - | — | - | |
| CHEMBL584103 | — | EC50 | - | — | - | |
| CHEMBL567227 | — | EC50 | - | — | - | |
| CHEMBL577730 | — | EC50 | - | — | - | |
| CHEMBL572214 | 1'-AMINEMETHYL-11-DEMETHYL-12-OXO-CALANOLIDE A | EC50 | - | — | - | |
| CHEMBL572213 | 1'-AZIDEMETHYL-11-DEMETHYL-12-OXO-CALANOLIDE A | EC50 | - | — | - |