Assay Detail
Functional
CHEMBL1041670
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 with reverse transcriptase G139I mutation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Highly suppressing wild-type HIV-1 and Y181C mutant HIV-1 strains by 10-chloromethyl-11-demethyl-12-oxo-calanolide A with druggable profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.95 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267447 | CALANOLIDE A | 1.0 | 1 | 8.66 |
| CHEMBL583253 | — | — | 1 | 6.99 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267447 | CALANOLIDE A | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL583253 | — | EC50 | = | 103.5 | nM | 6.99 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 6151.0 | nM | 5.21 |