Assay Detail
Functional
CHEMBL1041863
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at androgen receptor in human MDA-KB2 cells transfected with MMTV linked luciferase assessed as transcriptional activation by luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-KB2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.97 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084681 | — | — | 1 | 9.60 |
| CHEMBL3084525 | — | — | 1 | 8.80 |
| CHEMBL386630 | TESTOSTERONE | 4.0 | 1 | 8.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084681 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL3084525 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL386630 | TESTOSTERONE | EC50 | = | 3.162 | nM | 8.50 |