Assay Detail
ADMET
CHEMBL1042002
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Cytotoxicity against HEK293 cells after 48 hrs by MTT assay
14
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.79 | 6.89 |
| Activity | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570493 | — | — | 2 | 6.89 |
| CHEMBL570940 | — | — | 2 | 6.88 |
| CHEMBL566696 | — | — | 2 | 6.85 |
| CHEMBL576677 | — | — | 2 | 6.80 |
| CHEMBL567969 | — | — | 2 | 6.74 |
| CHEMBL585718 | — | — | 2 | 6.72 |
| CHEMBL576675 | — | — | 2 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570493 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL570940 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL566696 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL576677 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL567969 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL585718 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL576675 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL576675 | — | Activity | - | — | - | |
| CHEMBL585718 | — | Activity | - | — | - | |
| CHEMBL570940 | — | Activity | - | — | - | |
| CHEMBL576677 | — | Activity | - | — | - | |
| CHEMBL570493 | — | Activity | - | — | - | |
| CHEMBL566696 | — | Activity | - | — | - | |
| CHEMBL567969 | — | Activity | - | — | - |