Assay Detail
Binding
CHEMBL1042151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of gamma-secretase-mediated cleavage of human APP expressed in CHO cells assessed as reduction in amyloid beta42 production after 24 hrs by double sandwich ELISA
48
Total Activities
48
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 47 | - | - |
| EC50 | 1 | 7.54 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480558 | GSI-136 | 1.0 | 1 | 7.54 |
| CHEMBL576531 | — | — | 1 | - |
| CHEMBL577787 | — | — | 1 | - |
| CHEMBL576151 | — | — | 1 | - |
| CHEMBL573631 | — | — | 1 | - |
| CHEMBL576553 | — | — | 1 | - |
| CHEMBL573866 | — | — | 1 | - |
| CHEMBL575640 | — | — | 1 | - |
| CHEMBL575644 | — | — | 1 | - |
| CHEMBL584803 | — | — | 1 | - |
| CHEMBL576136 | — | — | 1 | - |
| CHEMBL572426 | — | — | 1 | - |
| CHEMBL572659 | — | — | 1 | - |
| CHEMBL574537 | — | — | 1 | - |
| CHEMBL574767 | — | — | 1 | - |
| CHEMBL577587 | — | — | 1 | - |
| CHEMBL572436 | — | — | 1 | - |
| CHEMBL573841 | — | — | 1 | - |
| CHEMBL578011 | — | — | 1 | - |
| CHEMBL574531 | — | — | 1 | - |
| CHEMBL576332 | — | — | 1 | - |
| CHEMBL572668 | — | — | 1 | - |
| CHEMBL579055 | — | — | 1 | - |
| CHEMBL575643 | — | — | 1 | - |
| CHEMBL564353 | — | — | 1 | - |
| CHEMBL574309 | — | — | 1 | - |
| CHEMBL572435 | — | — | 1 | - |
| CHEMBL573595 | — | — | 1 | - |
| CHEMBL577579 | — | — | 1 | - |
| CHEMBL574078 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480558 | GSI-136 | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL575642 | — | Activity | - | — | - | |
| CHEMBL573866 | — | Activity | - | — | - | |
| CHEMBL576553 | — | Activity | - | — | - | |
| CHEMBL573631 | — | Activity | - | — | - | |
| CHEMBL576151 | — | Activity | - | — | - | |
| CHEMBL577787 | — | Activity | - | — | - | |
| CHEMBL573303 | — | Activity | - | — | - | |
| CHEMBL576776 | — | Activity | - | — | - | |
| CHEMBL574519 | — | Activity | - | — | - | |
| CHEMBL577586 | — | Activity | - | — | - | |
| CHEMBL574525 | — | Activity | - | — | - | |
| CHEMBL578849 | — | Activity | - | — | - | |
| CHEMBL575640 | — | Activity | - | — | - | |
| CHEMBL573124 | — | Activity | - | — | - | |
| CHEMBL577166 | — | Activity | - | — | - | |
| CHEMBL574748 | — | Activity | - | — | - | |
| CHEMBL574326 | — | Activity | - | — | - | |
| CHEMBL574325 | — | Activity | - | — | - | |
| CHEMBL576354 | — | Activity | - | — | - | |
| CHEMBL576972 | — | Activity | - | — | - | |
| CHEMBL577800 | — | Activity | - | — | - | |
| CHEMBL579060 | — | Activity | - | — | - | |
| CHEMBL572425 | — | Activity | - | — | - | |
| CHEMBL574079 | — | Activity | - | — | - | |
| CHEMBL578011 | — | Activity | - | — | - | |
| CHEMBL574078 | — | Activity | - | — | - | |
| CHEMBL577579 | — | Activity | - | — | - | |
| CHEMBL573595 | — | Activity | - | — | - | |
| CHEMBL572435 | — | Activity | - | — | - | |
| CHEMBL574309 | — | Activity | - | — | - | |
| CHEMBL564353 | — | Activity | - | — | - | |
| CHEMBL575643 | — | Activity | - | — | - | |
| CHEMBL579055 | — | Activity | - | — | - | |
| CHEMBL572668 | — | Activity | - | — | - | |
| CHEMBL576332 | — | Activity | - | — | - | |
| CHEMBL574531 | — | Activity | - | — | - | |
| CHEMBL575644 | — | Activity | - | — | - | |
| CHEMBL573841 | — | Activity | - | — | - | |
| CHEMBL572436 | — | Activity | - | — | - | |
| CHEMBL576531 | — | Activity | - | — | - | |
| CHEMBL577587 | — | Activity | - | — | - | |
| CHEMBL574767 | — | Activity | - | — | - | |
| CHEMBL574537 | — | Activity | - | — | - | |
| CHEMBL572659 | — | Activity | - | — | - | |
| CHEMBL572426 | — | Activity | - | — | - | |
| CHEMBL576136 | — | Activity | - | — | - | |
| CHEMBL584803 | — | Activity | - | — | - |