Assay Detail
Functional
CHEMBL1042244
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in type B+ human erythrocytes assessed as inhibition of parasitemia after 48 hrs by Giemsa staining
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial pharmacodynamics of chalcone derivatives in combination with artemisinin against Plasmodium falciparum in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.13 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 10.52 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.40 |
| CHEMBL139702 | LICOAGROCHACONE A | — | 1 | 8.38 |
| CHEMBL495773 | — | — | 1 | 5.31 |
| CHEMBL526279 | — | — | 1 | 5.16 |
| CHEMBL497996 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL139702 | LICOAGROCHACONE A | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL495773 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL526279 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL497996 | — | IC50 | = | 9500.0 | nM | 5.02 |