Assay Detail
Binding
CHEMBL1042352
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Inhibition of para-aminophenylmercuric acetate-activated human recombinant pro-MMP9 catalytic domain after 4 hrs by fluorimetry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.13 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573715 | — | — | 1 | 9.10 |
| CHEMBL179288 | — | — | 1 | 8.17 |
| CHEMBL572780 | — | — | 1 | 7.16 |
| CHEMBL584365 | — | — | 1 | 7.03 |
| CHEMBL573714 | — | — | 1 | 7.01 |
| CHEMBL574370 | — | — | 1 | 6.51 |
| CHEMBL574605 | — | — | 1 | 6.47 |
| CHEMBL584122 | — | — | 1 | 6.39 |
| CHEMBL579067 | — | — | 1 | 6.38 |
| CHEMBL575896 | — | — | 1 | 6.16 |
| CHEMBL573936 | — | — | 1 | 6.14 |
| CHEMBL573934 | — | — | 1 | 6.03 |
| CHEMBL584147 | — | — | 1 | 5.52 |
| CHEMBL573935 | — | — | 1 | 5.14 |
| CHEMBL574589 | — | — | 1 | 5.11 |
| CHEMBL579068 | — | — | 1 | 4.70 |
| CHEMBL575895 | — | — | 1 | 4.62 |
| CHEMBL575881 | — | — | 1 | 4.62 |
| CHEMBL576762 | — | — | 1 | 4.29 |
| CHEMBL585376 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573715 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL179288 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL572780 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL584365 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL573714 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL574370 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL574605 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL584122 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL579067 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL575896 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL573936 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL573934 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL584147 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL573935 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL574589 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL579068 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL575895 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL575881 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL576762 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL585376 | — | IC50 | > | 100000.0 | nM | - |