Assay Detail
Binding
CHEMBL1042604
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Inhibition of c-jun phosphorylation in rat INS-1 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | INS1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.85 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL585951 | — | — | 1 | 7.27 |
| CHEMBL584899 | — | — | 1 | 7.09 |
| CHEMBL571023 | — | — | 1 | 7.08 |
| CHEMBL570554 | — | — | 1 | 7.05 |
| CHEMBL571434 | — | — | 1 | 6.85 |
| CHEMBL571626 | — | — | 1 | 6.68 |
| CHEMBL568116 | — | — | 1 | 6.58 |
| CHEMBL585725 | — | — | 1 | 6.55 |
| CHEMBL572283 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL585951 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL584899 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL571023 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL570554 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL571434 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL571626 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL568116 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL585725 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL572283 | — | IC50 | = | 350.0 | nM | 6.46 |