Compound Detail
CHEMBL571626
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL571626 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MDCMULVKRBERMG-UHFFFAOYSA-N |
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
407.5
MW (Da)
2.84
ALogP
8
HBA
2
HBD
114.7
PSA (Ų)
0.50
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 10 CHEMBL2637 | IC50 | 8.4 | 8.4 | 4.0 | 2 |
| Mitogen-activated protein kinase 8 CHEMBL2276 | IC50 | 7.8 | 7.8 | 16.0 | 2 |
| Mitogen-activated protein kinase 10 CHEMBL4092 | IC50 | 6.68 | 6.68 | 210.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.68 | 6.68 | 210.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 10 | IC50 | = | 4.0 | nM | 8.4 | Inhibition of JNK3 by time resolved fluorescence assay | 19947601 |
| Mitogen-activated protein kinase 10 | IC50 | = | 4.0 | nM | 8.4 | Inhibition of JNK3 (unknown origin) by time-resolved fluorescence assay | 25415535 |
| Mitogen-activated protein kinase 8 | IC50 | = | 16.0 | nM | 7.8 | Inhibition of JNK1 by time resolved fluorescence assay | 19947601 |
| Mitogen-activated protein kinase 8 | IC50 | = | 16.0 | nM | 7.8 | Inhibition of JNK1 (unknown origin) by time-resolved fluorescence assay | 25415535 |
| Unchecked | IC50 | = | 210.0 | nM | 6.68 | Inhibition of c-jun phosphorylation in rat INS-1 cells | 19947601 |
| Mitogen-activated protein kinase 10 | IC50 | = | 210.0 | nM | 6.68 | Inhibition of JNK3-mediated c-jun phosphorylation in rat INS1 cells | 25415535 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19947601 | 10.1021/jm901351f | Mitogen-activated protein kinase 10 | 2 |
| 19947601 | 10.1021/jm901351f | Unchecked | 2 |
| 25415535 | 10.1021/jm501212r | Mitogen-activated protein kinase 10 | 2 |
| 19947601 | 10.1021/jm901351f | Mitogen-activated protein kinase 8 | 1 |
| 25415535 | 10.1021/jm501212r | MAP kinase p38 | 1 |
| 25415535 | 10.1021/jm501212r | Mitogen-activated protein kinase 8 | 1 |
Data from ChEMBL 36 via Core Engine