Assay Detail
Binding
CHEMBL3395902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JNK3-mediated c-jun phosphorylation in rat INS1 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | INS1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase 10 (CHEMBL4092) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Inhibitors of c-Jun N-terminal kinases: an update.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.48 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3220495 | — | — | 1 | 8.52 |
| CHEMBL585951 | — | — | 1 | 7.27 |
| CHEMBL571626 | — | — | 1 | 6.68 |
| CHEMBL2144409 | — | — | 1 | 6.67 |
| CHEMBL1761554 | — | — | 1 | 6.51 |
| CHEMBL1233747 | — | — | 1 | 5.92 |
| CHEMBL3393599 | — | — | 1 | 5.89 |
| CHEMBL3393604 | — | — | 1 | 5.55 |
| CHEMBL2376930 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3220495 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL585951 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL571626 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2144409 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL1761554 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1233747 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3393599 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3393604 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2376930 | — | IC50 | = | 5300.0 | nM | 5.28 |