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Assay Detail

CHEMBL1042767

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Functional
Antiviral activity against HIV1 3B infected in human HOS cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type HOS
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Amine substituted N-(1H-benzimidazol-2ylmethyl)-5,6,7,8-tetrahydro-8-quinolinamines as CXCR4 antagonists with potent activity against HIV-1.
Gudmundsson KS, Sebahar PR, Richardson LD, Miller JF, Turner EM, Catalano JG, Spaltenstein A, Lawrence W, Thomson M, Jenkinson S.
Bioorg Med Chem Lett (2009) 19 : 5048 -5052
PubMed 19640718 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 7.34 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL570532 1 9.22
CHEMBL568653 1 8.70
CHEMBL568652 1 8.22
CHEMBL584896 1 8.16
CHEMBL518924 MAVORIXAFOR 4.0 1 8.00
CHEMBL583443 1 7.89
CHEMBL568447 1 7.77
CHEMBL565749 1 7.72
CHEMBL576429 1 7.66
CHEMBL578570 1 7.64
CHEMBL577021 1 7.62
CHEMBL568661 1 7.60
CHEMBL584075 1 7.58
CHEMBL577255 1 7.57
CHEMBL577486 1 7.48
CHEMBL568660 1 7.39
CHEMBL577268 1 7.36
CHEMBL578989 1 7.34
CHEMBL576427 1 6.87
CHEMBL568233 1 6.84
CHEMBL585750 1 6.71
CHEMBL585565 1 6.64
CHEMBL568234 1 6.61
CHEMBL565544 1 6.57
CHEMBL568245 1 6.40
CHEMBL568442 1 6.27
CHEMBL567586 1 5.89
CHEMBL565978 1 5.87

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL570532 IC50 = 0.6 nM 9.22
CHEMBL568653 IC50 = 2.0 nM 8.70
CHEMBL568652 IC50 = 6.0 nM 8.22
CHEMBL584896 IC50 = 6.9 nM 8.16
CHEMBL518924 MAVORIXAFOR IC50 = 10.0 nM 8.00
CHEMBL583443 IC50 = 13.0 nM 7.89
CHEMBL568447 IC50 = 17.0 nM 7.77
CHEMBL565749 IC50 = 19.0 nM 7.72
CHEMBL576429 IC50 = 22.0 nM 7.66
CHEMBL578570 IC50 = 23.0 nM 7.64
CHEMBL577021 IC50 = 24.0 nM 7.62
CHEMBL568661 IC50 = 25.0 nM 7.60
CHEMBL584075 IC50 = 26.0 nM 7.58
CHEMBL577255 IC50 = 27.0 nM 7.57
CHEMBL577486 IC50 = 33.0 nM 7.48
CHEMBL568660 IC50 = 41.0 nM 7.39
CHEMBL577268 IC50 = 44.0 nM 7.36
CHEMBL578989 IC50 = 46.0 nM 7.34
CHEMBL576427 IC50 = 134.0 nM 6.87
CHEMBL568233 IC50 = 144.0 nM 6.84
CHEMBL585750 IC50 = 197.0 nM 6.71
CHEMBL585565 IC50 = 228.0 nM 6.64
CHEMBL568234 IC50 = 243.0 nM 6.61
CHEMBL565544 IC50 = 271.0 nM 6.57
CHEMBL568245 IC50 = 396.0 nM 6.40
CHEMBL568442 IC50 = 540.0 nM 6.27
CHEMBL567586 IC50 = 1300.0 nM 5.89
CHEMBL565978 IC50 = 1350.0 nM 5.87