Assay Detail
Binding
CHEMBL1042902
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Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane after 60 mins
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Nucleoside-5'-monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5'-nucleotidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.30 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567801 | — | — | 1 | 6.86 |
| CHEMBL577036 | — | — | 1 | 6.75 |
| CHEMBL577915 | — | — | 1 | 6.59 |
| CHEMBL568023 | — | — | 1 | 6.40 |
| CHEMBL576838 | — | — | 1 | 6.34 |
| CHEMBL568009 | — | — | 1 | 6.30 |
| CHEMBL578569 | — | — | 1 | 6.27 |
| CHEMBL578819 | — | — | 1 | 6.26 |
| CHEMBL577458 | — | — | 1 | 6.03 |
| CHEMBL576883 | — | — | 1 | 6.00 |
| CHEMBL578145 | — | — | 1 | 5.94 |
| CHEMBL577902 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567801 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL577036 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL577915 | — | Ki | = | 256.0 | nM | 6.59 |
| CHEMBL568023 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL576838 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL568009 | — | Ki | = | 498.0 | nM | 6.30 |
| CHEMBL578569 | — | Ki | = | 532.0 | nM | 6.27 |
| CHEMBL578819 | — | Ki | = | 555.0 | nM | 6.26 |
| CHEMBL577458 | — | Ki | = | 927.0 | nM | 6.03 |
| CHEMBL576883 | — | Ki | = | 994.0 | nM | 6.00 |
| CHEMBL578145 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL577902 | — | Ki | = | 1270.0 | nM | 5.90 |