Assay Detail
Binding
CHEMBL1043333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U69593 from guinea pig cerebellum kappa opioid receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.72 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2016680 | — | — | 1 | 9.96 |
| CHEMBL1165548 | — | — | 1 | 9.82 |
| CHEMBL485605 | — | — | 1 | 9.65 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 9.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2016680 | — | Ki | = | 0.111 | nM | 9.96 |
| CHEMBL1165548 | — | Ki | = | 0.152 | nM | 9.82 |
| CHEMBL485605 | — | Ki | = | 0.225 | nM | 9.65 |
| CHEMBL19019 | NALTREXONE | Ki | = | 0.373 | nM | 9.43 |