Assay Detail
Binding
CHEMBL1043450
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Inhibition of TRKA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.02 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL578201 | — | — | 1 | 6.24 |
| CHEMBL576257 | — | — | 1 | 6.17 |
| CHEMBL570002 | — | — | 1 | 5.84 |
| CHEMBL569720 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL578201 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL576257 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL570002 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL569720 | — | IC50 | = | 1480.0 | nM | 5.83 |