High affinity nerve growth factor receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13High affinity nerve growth factor receptor shows approved-linked disease relevance led by cancer. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P04629. Start with cancer, then reuse UniProt P04629 as the stable protein anchor across project notes and exports.
Start with cancer, then reuse UniProt P04629 as the stable protein anchor across project notes and exports.
High affinity nerve growth factor receptor shows approved-linked disease relevance led by cancer. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with cancer because it currently carries approved-linked support. Linked drugs include REGORAFENIB, REPOTRECTINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyHigh affinity nerve growth factor receptor
Review this target as High affinity nerve growth factor receptor, mapped to UniProt P04629. Sequence length is 796 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats High affinity nerve growth factor receptor as ChEMBL target CHEMBL2815, mapped to UniProt P04629. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether High affinity nerve growth factor receptor is the right protein anchor across sources, using UniProt P04629 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why cancer is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.
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| Preferred Name | High affinity nerve growth factor receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P04629 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | High affinity nerve growth factor receptor |
| UniProt Accession | P04629 |
| Component Type | Protein |
| Sequence Length | 796 aa |
High affinity nerve growth factor receptor
Review this target as High affinity nerve growth factor receptor, mapped to UniProt P04629. Sequence length is 796 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
High affinity nerve growth factor receptor shows approved-linked disease relevance led by cancer. 5 more disease programs remain visible in the same review block.
Start review with cancer because it currently carries approved-linked support. Linked drugs include REGORAFENIB, REPOTRECTINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5914333 | 10.82 | Kd | 0.015 | Preclinical |
| CHEMBL6044141 | 10.51 | Kd | 0.031 | Preclinical |
| CHEMBL5770246 | 10.29 | Kd | 0.051 | Preclinical |
| CHEMBL5831552 | 10.19 | Kd | 0.065 | Preclinical |
| CHEMBL5963783 | 10.16 | IC50 | 0.069 | Preclinical |
| CHEMBL4297627 | 10.15 | IC50 | 0.07 | Clinical |
| CHEMBL5971833 | 10.09 | Kd | 0.082 | Preclinical |
| CHEMBL6060567 | 10.08 | IC50 | 0.083 | Preclinical |
| CHEMBL5902091 | 10.07 | Kd | 0.086 | Preclinical |
| CHEMBL5938707 | 10.06 | Kd | 0.088 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 787 | 2,594 | 7.5 |
| cell-based format | 202 | 692 | 7.1 |
| assay format | 131 | 1,700 | 7.6 |
| organism-based format | 2 | 12 | 7.4 |
| subcellular format | 1 | 24 | 6.3 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 2 | 5.8 |
| assay format | 2 | 6 | 6.6 |
| cell-based format | 1 | 1 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 17 | 6.6 |
| assay format | 2 | 239 | 6.2 |