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Compound Detail

CHEMBL5938707

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CN1Cc2cc(F)ccc2OCCNC(=O)c2cnc3ccc1nn23

Basic Information

ChEMBL ID CHEMBL5938707
Phase Preclinical
Structure Type MOL
InChI Key XMQOCSTWSHBZGY-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

341.4
MW (Da)
1.63
ALogP
6
HBA
1
HBD
71.8
PSA (Ų)
0.67
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H16FN5O2
MW 341.35
Aromatic Rings 3
Heavy Atoms 25
NP-Likeness -1.48

Activity Summary

Kd 2 meas. best 10.06

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
High affinity nerve growth factor receptor
CHEMBL2815
Kd 10.06 10.06 0.1 2

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine