Compound Detail
CHEMBL6060567
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Cn1ccc(-c2cc(C(=O)Nc3cnc(CN4C(=O)CNC4=O)nc3-c3ccccc3)c(F)cc2C(F)(F)F)n1
Basic Information
| ChEMBL ID | CHEMBL6060567 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WLZVWXUHEYDGFF-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
553.5
MW (Da)
4.01
ALogP
7
HBA
2
HBD
122.1
PSA (Ų)
0.28
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 10.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity nerve growth factor receptor CHEMBL2815 | IC50 | 10.08 | 10.08 | 0.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity nerve growth factor receptor | IC50 | = | 0.083 | nM | 10.08 | Functional Activity Assay: TrkA functional activity was measured using a Discove... | - |
Data from ChEMBL 36 via Core Engine