Assay Detail
ADMET
CHEMBL1043741
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Growth inhibition of HSMC
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HSMC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.41 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.22 |
| CHEMBL570493 | — | — | 1 | 7.82 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.75 |
| CHEMBL576677 | — | — | 1 | 7.46 |
| CHEMBL566696 | — | — | 1 | 7.46 |
| CHEMBL570940 | — | — | 1 | 7.26 |
| CHEMBL567969 | — | — | 1 | 7.16 |
| CHEMBL585718 | — | — | 1 | 7.00 |
| CHEMBL576675 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL570493 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL576677 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL566696 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL570940 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL567969 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL585718 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL576675 | — | IC50 | = | 300.0 | nM | 6.52 |