Assay Detail
Binding
CHEMBL1043963
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Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in CHO cells by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.65 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574595 | — | — | 1 | 7.07 |
| CHEMBL574623 | — | — | 1 | 7.01 |
| CHEMBL574700 | — | — | 1 | 6.98 |
| CHEMBL585740 | — | — | 1 | 6.88 |
| CHEMBL582945 | — | — | 1 | 6.88 |
| CHEMBL585741 | — | — | 1 | 6.63 |
| CHEMBL572490 | — | — | 1 | 6.42 |
| CHEMBL585742 | — | — | 1 | 6.34 |
| CHEMBL574627 | — | — | 1 | 6.19 |
| CHEMBL575203 | — | — | 1 | 6.10 |
| CHEMBL574558 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574595 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL574623 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL574700 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL585740 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL582945 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL585741 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL572490 | — | Ki | = | 381.0 | nM | 6.42 |
| CHEMBL585742 | — | Ki | = | 457.0 | nM | 6.34 |
| CHEMBL574627 | — | Ki | = | 648.0 | nM | 6.19 |
| CHEMBL575203 | — | Ki | = | 799.0 | nM | 6.10 |
| CHEMBL574558 | — | Ki | > | 1000.0 | nM | - |