Assay Detail
Functional
CHEMBL1044053
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Cytotoxicity against human A431 cells after 72 hrs by SRB assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a novel Her-1/Her-2 dual tyrosine kinase inhibitor for the treatment of Her-1 selective inhibitor-resistant non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.22 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570800 | — | — | 1 | 8.22 |
| CHEMBL569880 | — | — | 1 | 8.15 |
| CHEMBL571040 | — | — | 1 | 8.10 |
| CHEMBL572160 | — | — | 1 | 7.96 |
| CHEMBL569871 | — | — | 1 | 7.96 |
| CHEMBL571718 | — | — | 1 | 7.75 |
| CHEMBL585373 | — | — | 1 | 7.64 |
| CHEMBL567181 | — | — | 1 | 7.57 |
| CHEMBL571945 | — | — | 1 | 7.50 |
| CHEMBL571927 | — | — | 1 | 7.42 |
| CHEMBL571286 | — | — | 1 | 7.16 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 7.02 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 6.98 |
| CHEMBL565239 | — | — | 1 | 6.98 |
| CHEMBL567401 | — | — | 1 | 6.66 |
| CHEMBL568266 | — | — | 1 | 6.54 |
| CHEMBL570361 | — | — | 1 | 6.46 |
| CHEMBL568486 | — | — | 1 | 6.29 |
| CHEMBL568956 | — | — | 1 | 6.25 |
| CHEMBL570118 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570800 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL569880 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL571040 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL572160 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL569871 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL571718 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL585373 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL567181 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL571945 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL571927 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL571286 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL554 | LAPATINIB | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL565239 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL567401 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL568266 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL570361 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL568486 | — | IC50 | = | 513.0 | nM | 6.29 |
| CHEMBL568956 | — | IC50 | = | 567.0 | nM | 6.25 |
| CHEMBL570118 | — | IC50 | = | 1400.0 | nM | 5.85 |