Assay Detail
Binding
CHEMBL1044055
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Inhibition of Her1 by fluorescence polarization assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of a novel Her-1/Her-2 dual tyrosine kinase inhibitor for the treatment of Her-1 selective inhibitor-resistant non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.74 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569880 | — | — | 1 | 8.05 |
| CHEMBL571040 | — | — | 1 | 7.89 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 7.28 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569880 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL571040 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL554 | LAPATINIB | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL553 | ERLOTINIB | IC50 | > | 1000.0 | nM | - |