Assay Detail
Binding
CHEMBL1044463
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Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.26 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL568173 | — | — | 1 | 7.34 |
| CHEMBL191528 | ETHOXYCOUMARIN | — | 1 | 6.00 |
| CHEMBL572366 | — | — | 1 | 5.42 |
| CHEMBL145781 | 7-BENZYLOXYCOUMARIN | — | 1 | 5.34 |
| CHEMBL571519 | — | — | 1 | 5.32 |
| CHEMBL568348 | — | — | 1 | 5.19 |
| CHEMBL568385 | — | — | 1 | 5.18 |
| CHEMBL567139 | — | — | 1 | 5.15 |
| CHEMBL571514 | 7-BUTOXYCOUMARIN | — | 1 | 5.14 |
| CHEMBL568416 | — | — | 1 | 5.14 |
| CHEMBL568516 | 7-PROPOXYCOUMARIN | — | 1 | 5.13 |
| CHEMBL567896 | — | — | 1 | 5.13 |
| CHEMBL571738 | — | — | 1 | 5.13 |
| CHEMBL577123 | — | — | 1 | 5.11 |
| CHEMBL578167 | — | — | 1 | 5.09 |
| CHEMBL49732 | HERNIARIN | — | 1 | 5.08 |
| CHEMBL568417 | — | — | 1 | 5.07 |
| CHEMBL83294 | COUMARIN-3-CARBOXYLIC ACID | — | 1 | 5.06 |
| CHEMBL12567 | — | — | 1 | 5.02 |
| CHEMBL567544 | — | — | 1 | 5.02 |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL568173 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL191528 | ETHOXYCOUMARIN | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL572366 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL145781 | 7-BENZYLOXYCOUMARIN | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL571519 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL568348 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL568385 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL567139 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL571514 | 7-BUTOXYCOUMARIN | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL568416 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL568516 | 7-PROPOXYCOUMARIN | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL567896 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL571738 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL577123 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL578167 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL49732 | HERNIARIN | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL568417 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL83294 | COUMARIN-3-CARBOXYLIC ACID | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL12567 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL567544 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL6466 | COUMARIN | Ki | = | 39600.0 | nM | 4.40 |