Assay Detail
Functional
CHEMBL1044606
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Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Studies towards topical selective beta2-adrenoceptor agonists with a long duration of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 8.76 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 9.40 |
| CHEMBL576428 | — | — | 1 | 9.30 |
| CHEMBL568239 | — | — | 1 | 9.05 |
| CHEMBL587197 | — | — | 1 | 9.00 |
| CHEMBL577917 | — | — | 1 | 9.00 |
| CHEMBL577702 | — | — | 1 | 8.96 |
| CHEMBL583235 | — | — | 1 | 8.92 |
| CHEMBL570834 | — | — | 1 | 8.92 |
| CHEMBL585751 | — | — | 1 | 8.74 |
| CHEMBL565770 | — | — | 1 | 8.39 |
| CHEMBL565747 | — | — | 1 | 8.27 |
| CHEMBL568667 | — | — | 1 | 8.05 |
| CHEMBL585382 | — | — | 1 | 7.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1256786 | FORMOTEROL | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL576428 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL568239 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL587197 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL577917 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL577702 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL583235 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL570834 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL585751 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL565770 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL565747 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL568667 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL585382 | — | EC50 | = | 11.6 | nM | 7.94 |