Assay Detail
Functional
CHEMBL1044684
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Antiinflammatory activity in human whole blood assessed as inhibition of LPS-induced TNFalpha production treated 15 mins before LPS challenge by ELISA
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.99 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571060 | — | — | 1 | 8.22 |
| CHEMBL570939 | — | — | 1 | 7.82 |
| CHEMBL1204128 | — | — | 1 | 7.70 |
| CHEMBL568446 | — | — | 1 | 7.52 |
| CHEMBL1204129 | — | — | 1 | 7.40 |
| CHEMBL1204131 | — | — | 1 | 7.10 |
| CHEMBL1204130 | — | — | 1 | 7.05 |
| CHEMBL568232 | — | — | 1 | 7.05 |
| CHEMBL585566 | — | — | 1 | 7.00 |
| CHEMBL571029 | — | — | 1 | 7.00 |
| CHEMBL591662 | — | — | 1 | 7.00 |
| CHEMBL578359 | — | — | 1 | 6.72 |
| CHEMBL372575 | — | — | 1 | 6.70 |
| CHEMBL584475 | — | — | 1 | 6.70 |
| CHEMBL567585 | — | — | 1 | 6.68 |
| CHEMBL565558 | — | — | 1 | 6.52 |
| CHEMBL586818 | — | — | 1 | 6.52 |
| CHEMBL571022 | — | — | 1 | 6.52 |
| CHEMBL579266 | — | — | 1 | 6.40 |
| CHEMBL570839 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571060 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL570939 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1204128 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL568446 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1204129 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1204131 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1204130 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL568232 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL585566 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL571029 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL591662 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL578359 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL372575 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL584475 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL567585 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL565558 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL586818 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL571022 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL579266 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL570839 | — | IC50 | = | 800.0 | nM | 6.10 |