Assay Detail
Binding
CHEMBL1044690
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Inhibition of Cy3-labeled mouse recombinant Hes1 (3-281) dimer formation expressed in Escherichia coli by microplate-based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The first Hes1 dimer inhibitors from natural products.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.97 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL565404 | LINDBLADIONE | — | 1 | 5.39 |
| CHEMBL491841 | LYCOGALIC ACID A | — | 1 | 5.22 |
| CHEMBL572017 | — | — | 1 | 5.11 |
| CHEMBL466738 | NUDIPOSIDE | — | 1 | 5.02 |
| CHEMBL439675 | LYCOGARUBIN B | — | 1 | 4.78 |
| CHEMBL583884 | LYONISIDE | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL565404 | LINDBLADIONE | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL491841 | LYCOGALIC ACID A | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL572017 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL466738 | NUDIPOSIDE | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL439675 | LYCOGARUBIN B | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL583884 | LYONISIDE | IC50 | = | 48100.0 | nM | 4.32 |