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Assay Detail

CHEMBL1044765

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Beta-2 adrenergic receptor (CHEMBL210)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Use of 5-hydroxy-4H-benzo[1,4]oxazin-3-ones as beta2-adrenoceptor agonists.
Hoenke C, Bouyssou T, Tautermann CS, Rudolf K, Schnapp A, Konetzki I.
Bioorg Med Chem Lett (2009) 19 : 6640 -6644
PubMed 19875286 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 22 8.73 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL579394 1 10.00
CHEMBL568272 1 10.00
CHEMBL567863 1 9.70
CHEMBL584498 1 9.40
CHEMBL1256786 FORMOTEROL 4.0 1 9.40
CHEMBL567833 1 9.40
CHEMBL565267 1 9.30
CHEMBL568273 1 9.22
CHEMBL567192 1 9.22
CHEMBL568531 1 9.15
CHEMBL576848 1 8.82
CHEMBL565686 1 8.77
CHEMBL577289 1 8.55
CHEMBL566973 1 8.54
CHEMBL565685 1 7.87
CHEMBL566777 1 7.70
CHEMBL568511 1 7.16
CHEMBL566352 1 6.88
CHEMBL566992 1 6.77
CHEMBL566353 1 -
CHEMBL567843 1 -
CHEMBL568060 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL579394 EC50 = 0.1 nM 10.00
CHEMBL568272 EC50 = 0.1 nM 10.00
CHEMBL567863 EC50 = 0.2 nM 9.70
CHEMBL584498 EC50 = 0.4 nM 9.40
CHEMBL1256786 FORMOTEROL EC50 = 0.4 nM 9.40
CHEMBL567833 EC50 = 0.4 nM 9.40
CHEMBL565267 EC50 = 0.5 nM 9.30
CHEMBL568273 EC50 = 0.6 nM 9.22
CHEMBL567192 EC50 = 0.6 nM 9.22
CHEMBL568531 EC50 = 0.7 nM 9.15
CHEMBL576848 EC50 = 1.5 nM 8.82
CHEMBL565686 EC50 = 1.7 nM 8.77
CHEMBL577289 EC50 = 2.8 nM 8.55
CHEMBL566973 EC50 = 2.9 nM 8.54
CHEMBL565685 EC50 = 13.4 nM 7.87
CHEMBL566777 EC50 = 20.0 nM 7.70
CHEMBL568511 EC50 = 70.0 nM 7.16
CHEMBL566352 EC50 = 131.0 nM 6.88
CHEMBL566992 EC50 = 170.0 nM 6.77
CHEMBL566353 EC50 > 10000.0 nM -
CHEMBL567843 EC50 > 10000.0 nM -
CHEMBL568060 EC50 > 10000.0 nM -