Assay Detail
Binding
CHEMBL1044771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]IMPY from beta-amyloid plaques in Alzheimer's disease patient brain homogenate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of three 18F-labeled aminophenylbenzothiazoles as amyloid imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.32 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | 2.0 | 1 | 8.55 |
| CHEMBL566354 | — | — | 1 | 8.42 |
| CHEMBL578982 | — | — | 1 | 8.39 |
| CHEMBL510384 | — | — | 1 | 8.24 |
| CHEMBL568061 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL566354 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL578982 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL510384 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL568061 | — | Ki | = | 10.0 | nM | 8.00 |