Assay Detail
Functional
CHEMBL1044815
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Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Imax | 2 | - | - |
| IC50 | 2 | 4.60 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574700 | — | — | 2 | 4.70 |
| CHEMBL582945 | — | — | 2 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574700 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL582945 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL582945 | — | Imax | = | 100.0 | % | - |
| CHEMBL574700 | — | Imax | = | 70.0 | % | - |