Assay Detail
Functional
CHEMBL1044820
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Agonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.67 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.82 |
| CHEMBL582945 | — | — | 1 | 6.70 |
| CHEMBL574700 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL582945 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL574700 | — | EC50 | = | 330.0 | nM | 6.48 |